When Was Semaglutide Invented?

Introduction

Semaglutide is now one of the most widely discussed medications for both type 2 diabetes and weight loss. Known by brand names like Ozempic, Wegovy, and Rybelsus, it has transformed the way doctors approach obesity and metabolic health. But many people wonder: when was semaglutide actually invented, and how did it become such a breakthrough treatment?

The Origin of Semaglutide

Semaglutide was developed by Novo Nordisk, a global pharmaceutical company based in Denmark. The invention traces back to the early 2000s, when researchers were working on improving existing GLP-1 receptor agonists such as liraglutide (marketed as Victoza). These medications mimic the action of the natural hormone GLP-1, which helps regulate blood sugar and appetite.

While liraglutide was already effective, its shorter half-life required daily injections. Scientists wanted to create a longer-acting version that could be taken weekly instead of daily. Through years of research and modification of the GLP-1 molecule, semaglutide was officially discovered in 2012 as a longer-lasting and more potent option.

Development and Approval Timeline

After its discovery in 2012, semaglutide underwent rigorous clinical trials to test its safety and effectiveness. Novo Nordisk submitted the drug for regulatory approval, and the U.S. Food and Drug Administration (FDA) approved Ozempic in December 2017 for the treatment of type 2 diabetes.

Later, in 2021, the FDA approved semaglutide under the brand name Wegovy for chronic weight management. This marked a turning point, as it was the first time a GLP-1 drug was widely approved for obesity, opening doors to its widespread use for weight loss. Additionally, Rybelsus, an oral version of semaglutide, was approved in 2019, becoming the first pill form of a GLP-1 receptor agonist.

Why Semaglutide Was a Breakthrough

The invention of semaglutide represented a huge leap forward in diabetes and obesity care. By extending the drug’s half-life, researchers made it possible for patients to inject the medication just once a week rather than daily. This not only improved convenience but also adherence, which is critical for long-term success. Beyond diabetes, its powerful effect on appetite and weight loss brought a new option for millions struggling with obesity worldwide.

FAQs About the Invention of Semaglutide

Who invented semaglutide?
Semaglutide was developed by researchers at Novo Nordisk, a Danish pharmaceutical company specializing in diabetes and obesity treatments.

When was semaglutide first discovered?
It was discovered in 2012 as part of Novo Nordisk’s research into longer-acting GLP-1 receptor agonists.

When did semaglutide become available to the public?
Ozempic (for type 2 diabetes) was approved by the FDA in 2017. Wegovy (for weight loss) was approved in 2021, and Rybelsus (oral form) was approved in 2019.

Why did researchers create semaglutide if liraglutide already existed?
Semaglutide was designed to be longer-lasting and more effective, allowing for weekly dosing instead of daily injections.

Final Thoughts

Semaglutide was officially discovered in 2012 and first approved for use in 2017. In less than a decade, it has revolutionized the treatment of diabetes and obesity, becoming one of the most impactful medical breakthroughs in recent years. What began as an improvement on earlier GLP-1 drugs is now shaping the future of weight management and metabolic health around the world.